Critical illness is the result of the interplay of complex physiology, complex decision making and a complex environment. ICCAI gathers outstanding mathematicians, engineers, biological scientists, clinicians and industry participants to present recent advances in filling the translation gap between advances in quantitative sciences and improved bedside decision making resulting in improved patient outcomes.

The 11th International Conference on Complexity in Acute Illness (ICCAI) will welcome attendees from North America, Europe, and Asia to share their insights and perspectives on complexity in acute illness. The meeting will include presentations and discussions focused on quantitative, innovative, transdisciplinary, and clinically relevant research highlighting leading edge science.

We are looking forward to a very successful meeting and hope to see you in September!

Inflammation and organ dysfunction that accompany trauma and sepsis are complex, multi-focal problems. Enormous amount of money, both public and private, have been spent on research and clinical care for this constellation of diseases. Though exciting laboratory breakthroughs derived from reductionist approaches await translation to the clinic, few therapeutic options are available today. New paradigms are needed to truly impact care for acute illness.

We formed the Society for Complexity in Acute Illness (SCAI) because we believe passionately that complex systems approaches, involving modeling, simulation, systems biology, chaos theory, and network theory can augment the classical, hypothesis-driven approach that has largely failed to stem the tide of critical illness.

We are clinicians, bench scientists, and modelers. We work in hospitals, research institutions, and companies. We have made large strides in modeling inflammation and organ dysfunction. Our work has been funded both by government and business, and has been presented in major scientific meetings.

This year ICCAI will take place at the beautiful Marriott Hotel right in the heart of downtown Ottawa.

This luxurious hotel is located close to the Parliament Buildings, the Rideau Canal, the Rideau Centre, the National Gallery of Canada and the Byward Market.

Meeting activities will commence Thursday morning (September 6th) and end early Sunday afternoon (September 9th). The meeting will begin with workshops, followed by speaker sessions, and abstract and poster presentations throughout the conference. A gala dinner for all attendees will be held Saturday night at the Merlot Rooftop Grill, the Marriott's revolving restaurant, offering a spectacular view of Ottawa. Throughout the meeting there will be ample "open" time allowing attendees to collaborate, network, and share discussions.

Insights in complexity and health care Mechanisitic models in vivo and in silico Transdisciplinary exploration of complexity Origins of Complex Variability Redefining the characterization and treatment of acute illness Advanced quantitative and complexity analysis Respiratory Failure and Ventilator-Human Interaction Gathering and Analyzing high-dimensional data at the bedside Network Structure in complex systems Variability monitoring at the bedside Future challenges/Feedback

Annual ICCAI run Gala Dinner

Gary An, MD Ryan Arnold, MD Giuseppe Baselli, PhD Andriy Batchinsky, MD Jason Bates, PhD Sc Tim Buchman, PhD MD Leopoldo C. Cancio, MD Marie Csete, PhD, MD Judy Day, PhD Claudia DosSantos, MD, MSc John Doyle, PhD Wassim Haddad, PhD Mary Ellen Harper, PhD Steven Hollenberg, MD Frank Jacono, MD Alistair Johnson, PhD Candidate Curt Lindberg, MHA, PhD Andre Longtin, PhD Ralph Lorenz, PhD John Marshall, MD, FRCSC Doug McNair, MD PhD Randall Moorman, MD Edmund Neugebauer, PhD Stephen Rees, PhD Jose Salinas, PhD John Scott, MD, PhD Andrew Seely, MD, PhD, FRCSC Daby Sow, PhD Duncan Stewart, MD, FRCSC Bela Suki, PhD Yoram Vodovotz, PhD Neils Wessel, PhD Jan Zebrowski, PhD Sven Zenker, MD Brenda Zimmerman, MBA, PhD

Special opportunities for collaboration Sponsored social events Workshops Abstract Presentations - Podium and Poster Discounted registration fee! $200.

The 7th Conference of the European Study Group on Cardiovascular Oscillations will focus on basic research on cardiovascular oscillations at the interface between physiology and clinical medicine. The main topics of the conference will include heart rate, breathing and blood pressure variability, instabilities and complexity in regulatory processes as well as cardiovascular oscillations in stress and disease including critical care, fetal development and other clinical applications.

The 7th International Workshop on Biosignal Interpretation aims at exploring the fields of biosignal interpretation including model based signal analysis, data interpretation and integration, medical decision making extending the existing signal processing methods and technologies for the effective utilization of biosignals in a clinical environment as well as for a deeper understanding of biological functions from the whole organism, system, to cellular, protein and gene scales.